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154447-36-6
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
It inhibits Wee1 in H3K36me3-deficient cells results in RRM2 reduction
437(7057):436-9
InChiKey: UCINOBZMLCREGM-RNNUGBGQSA-N
AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid 154447-36-6AK 7, CAS No. 420831 40 9, is a cell and brain permeable, selective sirtuin SIRT2 inhibitor (IC50 ~15. 5 M). AK 7 displays no effect on SIRT1 or SIRT3. It diminishes neuronal cell death induced by mutant huntingtin fragment. It also down regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. In two genetic mouse models of Huntingtons disease, AK 7 treatment resulted in improved motor function,
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