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16(11):1069-79
LPS-induced TNF-alpha production in mice
Epub 2019 Oct 4
InChi: InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H
VH-032 amide-alkylC3-amine
Tubastatin A Hydrochloride - CAS# 1310693-92-5 riquidar (methanesulfonate hydrate) 16(11):1069-79Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A demonstrates 1093 fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16. 4 M for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000 fold selectivity against all other HDAC isoforms (IC50 >16