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WDR5-C47 could serve as a tool compound to study functions of SET1-family of human histone methyltransferases and further develop therapeutic drug molecules targeting the WDR5−MLL interaction
CAS Number: 1184136-10-4
inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines
2ClH/c1-14(19(26(3)4)16-10-6-5-7-11-16)22-20-17-12-8-9-13-18(17)21-24-23-15(2)27(21)25-20
GSK 1349572
AG-82 p2m myristoylated TFA WDR5-C47 could serve as aAG 82 is a cell permeable, reversible, and competitive inhibitor of tyrosine kinase and epidermal growth factor (EGF) receptor. Protein tyrosine kinases (PTKs) have been involved in regulating cell proliferation, cell differentiation, and signaling processes in the immune system. Dysfunction of protein tyrosine kinases result in inflammatory responses and diseases including cancer, atherosclerosis, and psoriasis . The epidermal growth factor receptor
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